CDH6 Antibody

Datasheet

中文名称：

CDH6兔多克隆抗体
货号：

CSB-PA004767
规格：

￥880
图片：
Western Blot analysis of BT474 A549 SHSY5Y 293 cells using K-cadherin Polyclonal Antibody
其他：

产品详情

Uniprot No.：

P55285
基因名：

CDH6
别名：

CDH6; Cadherin-6; Kidney cadherin; K-cadherin
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human K-cadherin.
免疫原种属：

Homo sapiens (Human)
标记方式：

Non-conjugated
抗体亚型：

IgG
纯化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
产品提供形式：

Liquid
应用范围：

WB, ELISA

推荐稀释比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

功能：

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
基因功能参考文献：
1. Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC PMID: 27593557
2. The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells. PMID: 20634887
亚细胞定位：

Cell membrane; Single-pass type I membrane protein.
组织特异性：

Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
数据库链接：

HGNC: 1765

OMIM: 603007

KEGG: hsa:1004

STRING: 9606.ENSP00000265071

UniGene: Hs.124776