CD33

CD33又名氨基肽酶N（APN），是一种跨膜糖蛋白，属于唾液酸结合免疫球蛋白样凝集素的一员。CD33在交联或者配体结合后激活，介导抑制信号，调节细胞内钙动员、细胞粘附、白血病细胞凋亡、髓系细胞成熟和细胞因子的产生等等。CD33在90%以上的急性髓系白血病患者都有表达。在造血干细胞表面没有表达，在成熟的粒细胞和其他组织也没有表达，CD33作为髓系白血病治疗的潜力靶点，一批企业相继布局了CD33药物的研发，辉瑞的靶向CD33的ADC药物Mylotarg已获批上市。除了ADC药物外，靶向CD33的双抗药物和CAR-T细胞疗法亦在如火如荼地研发中。

Recombinant Human CD33 活性蛋白实验验证数据

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC₅₀ of human CD33 protein is 4.289- 5.312 ng/ml.

CD33 Antibody

CD33 Protein

CD33 ELISA Kit

CD33 Antibodies

CD33 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA004925GA01HU	CD33 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA004925ESR1HU	CD33 Antibody	Human	ELISA, WB, IHC
CSB-PA004925ESR2HU	CD33 Antibody	Human	ELISA, IHC
CSB-PA006175	CD33 Antibody	Human	WB, ELISA
CSB-PA070366	CD33 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA243594	CD33 Antibody	Human	ELISA,WB,IHC
CSB-PA004925LA01HU	CD33 Antibody	Human	ELISA, WB, IHC
CSB-PA004925LD01HU	CD33 Antibody, Biotin conjugated	Human	ELISA

CD33 Proteins

CD33 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP004925HU CSB-BP004925HU CSB-EP004925HU-B	Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004925HU(A4)	Recombinant Human Myeloid cell surface antigen CD33 (CD33)	in vitro E.coli expression system
CSB-MP004925HU	Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	Mammalian cell

CD33 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP730931MO CSB-EP730931MO CSB-BP730931MO CSB-MP730931MO CSB-EP730931MO-B	Recombinant Mouse Myeloid cell surface antigen CD33 (Cd33), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli