TGF-beta signaling pathway

转化生长因子β (TGF-β) 超家族信号转导在众多生物系统中对细胞生长、分化和发育的调节发挥重要作用。一般而言，信号转导起始于配体诱导的丝氨酸/苏氨酸受体激酶寡聚化和胞浆信号转导分子Smad2 和 Smad3等的磷酸化。Smads 的羧基端被活化受体磷酸化后导致其与常见信号转导因子 Smad4 结合，并转运入胞核。激活的Smads可通过与转录因子结合，调节各种不同的生物学效应，导致细胞状态特异性转录调节。正如下图所示，转化生长因子包括Activin、TGFβ和BMP，一旦与相应的受体结合后，会使细胞内信号转到分子Smads磷酸化，从而激活信号通路。

Target	Antibody	Protein	ELISA Kit
INHBE	INHBE Antibody	INHBE Protein	INHBE ELISA Kit
LEFTY1	LEFTY1 Antibody	LEFTY1 Protein	LEFTY1 ELISA Kit
LEFTY2	LEFTY2 Antibody	LEFTY2 Protein	LEFTY2 ELISA Kit
LTBP1	LTBP1 Antibody	LTBP1 Protein	LTBP1 ELISA Kit
MAPK1	MAPK1 Antibody	MAPK1 Protein	MAPK1 ELISA Kit
MAPK3	MAPK3 Antibody	MAPK3 Protein	MAPK3 ELISA Kit
MYC	MYC Antibody	MYC Protein	MYC ELISA Kit
NODAL	NODAL Antibody	NODAL Protein	NODAL ELISA Kit
NOG	NOG Antibody	NOG Protein	NOG ELISA Kit
PITX2	PITX2 Antibody	PITX2 Protein	PITX2 ELISA Kit
PPP2CA	PPP2CA Antibody	PPP2CA Protein	PPP2CA ELISA Kit
PPP2CB	PPP2CB Antibody	PPP2CB Protein	PPP2CB ELISA Kit
PPP2R1A	PPP2R1A Antibody	PPP2R1A Protein	PPP2R1A ELISA Kit
PPP2R1B	PPP2R1B Antibody	PPP2R1B Protein	PPP2R1B ELISA Kit
RBL1	RBL1 Antibody	RBL1 Protein	RBL1 ELISA Kit
RBX1	RBX1 Antibody	RBX1 Protein	RBX1 ELISA Kit
RHOA	RHOA Antibody	RHOA Protein	RHOA ELISA Kit
ROCK1	ROCK1 Antibody	ROCK1 Protein	ROCK1 ELISA Kit
RPS6KB1	RPS6KB1 Antibody	RPS6KB1 Protein	RPS6KB1 ELISA Kit
RPS6KB2	RPS6KB2 Antibody	RPS6KB2 Protein	RPS6KB2 ELISA Kit